校内邮箱

学院新闻    
当前位置: 学院新闻
吴晓进教授和罗德平教授课题组在JACS发表研究论文
阅读次数:322 添加时间:2018/6/27 发布: 管理员
【字体: 字体颜色

Palladium-Catalyzed Regiocontrollable Reductive Heck Reaction of Unactivated Aliphatic Alkenes

Chengdong Wang,a Guanlin Xiao,a Tao Guo,a Yalan Ding,a Xiaojin Wu*,a and Teck-Peng Loh*,ab

 

a Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing 211816, P. R. China

b Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637616

Abstract: A general Pd-catalyzed intermolecular reductive Heck reaction of both terminal and internal unactivated aliphatic alkenes has been firstly developed. This method affords γ- and δ-arylated alkyl carboxylic acid derivatives in high yields with complete anti-Markovnikov selectivity. Notably, the coupling process is stereoretentive for the alkyl chain. Mechanistically, alkyl palladacycle intermediates stabilized by directing group and ligand, hydride species multi-generated from PS/TFA reductant, are two key factors that successfully promote the reaction and regioselectivity.

 

JACS. 2018, DOI: 10.1021/jacs.8b03619 (2017年影响因子: 13.858,第一作者为硕士研究生王成东).

论文链接: https://pubs.acs.org/doi/pdf/10.1021/jacs.8b03619

 

(转载自:http://ias.njtech.edu.cn/ch/view.asp?id=1802&class=165

 



地址南京浦口区浦珠南路30号 邮编:210009 电话:025-58139535、9536、9537 邮箱:chem@njtech.edu.cn
版权所有(c)龙8的手机登录网址